Toxicological Sciences

REVIEW

Get checked abstract Richard M. LoPachin, David S. Barber, and Terrence Gavin

Molecular Mechanisms of the Conjugated ,β-Unsaturated Carbonyl Derivatives: Relevance to Neurotoxicity and Neurodegenerative Diseases
ToxSci Advance Access published on December 13, 2007
Toxicol. Sci. 2008 104: 235-249; doi:10.1093/toxsci/kfm301 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Marina V. Evans, Sean M. Dowd, Elaina M. Kenyon, Michael F. Hughes, and Hisham A. El-Masri

A Physiologically based Pharmacokinetic Model for Intravenous and Ingested Dimethylarsinic Acid in Mice
ToxSci Advance Access published on April 21, 2008
Toxicol. Sci. 2008 104: 250-260; doi:10.1093/toxsci/kfn080 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Lauren M. Aleksunes, Sarah N. Campion, Michael J. Goedken, and José E. Manautou

Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes
ToxSci Advance Access published on May 8, 2008
Toxicol. Sci. 2008 104: 261-273; doi:10.1093/toxsci/kfn093 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

CARCINOGENICITY

Get checked abstract Yuichi Kuroiwa, Masami Yamada, Keiko Matsui, Toshiya Okamura, Yuji Ishii, Ken-ichi Masumura, Masako Tasaki, Takashi Umemura, Kunitoshi Mitsumori, Takehiko Nohmi, Masao Hirose, and Akiyoshi Nishikawa

Combined Ascorbic Acid and Sodium Nitrite Treatment Induces Oxidative DNA Damage-Associated Mutagenicity In Vitro, but Lacks Initiation Activity in Rat Forestomach Epithelium
ToxSci Advance Access published on April 22, 2008
Toxicol. Sci. 2008 104: 274-282; doi:10.1093/toxsci/kfn081 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Rong-Jane Chen, Yuan-Soon Ho, How-Ran Guo, and Ying-Jan Wang

Rapid Activation of Stat3 and ERK1/2 by Nicotine Modulates Cell Proliferation in Human Bladder Cancer Cells
ToxSci Advance Access published on April 30, 2008
Toxicol. Sci. 2008 104: 283-293; doi:10.1093/toxsci/kfn086 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Chia-Chi Ho, Yong-Chien Ling, Louis W. Chang, Hui-Ti Tsai, Ming-Hsien Tsai, and Pinpin Lin

17-Beta Estradiol and Hydroxyestradiols Interact via the NF-Kappa B Pathway to Elevate Cyclooxygenase 2 Expression and Prostaglandin E2 Secretion in Human Bronchial Epithelial Cells
ToxSci Advance Access published on May 13, 2008
Toxicol. Sci. 2008 104: 294-302; doi:10.1093/toxsci/kfn096 [Abstract] [Full Text] [PDF] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

IMMUNOTOXICOLOGY

Get checked abstract Margaret M. Whalen, Jamie C. DeWitt, and Robert W. Luebke

Serum Supplementation Modulates the Effects of Dibutyltin on Human Natural Killer Cell Function
ToxSci Advance Access published on April 25, 2008
Toxicol. Sci. 2008 104: 312-319; doi:10.1093/toxsci/kfn082 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Jürgen Pauluhn

Brown Norway Rat Asthma Model of Diphenylmethane-4,4'-Diisocyanate (MDI): Analysis of the Elicitation Dose-Response Relationship
ToxSci Advance Access published on May 20, 2008
Toxicol. Sci. 2008 104: 320-331; doi:10.1093/toxsci/kfn098 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Cintia Konjuh, Graciela García, Lidia López, Ana María Evangelista de Duffard, Alicia Brusco, and Ricardo Duffard

Neonatal Hypomyelination by the Herbicide 2,4-Dichlorophenoxyacetic Acid. Chemical and Ultrastructural Studies in Rats
ToxSci Advance Access published on May 5, 2008
Toxicol. Sci. 2008 104: 332-340; doi:10.1093/toxsci/kfn085 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Ke Yu, Yuhe He, Leo W. Y. Yeung, Paul K. S. Lam, Rudolf S. S. Wu, and Bingsheng Zhou

DE-71-Induced Apoptosis Involving Intracellular Calcium and the Bax-Mitochondria-Caspase Protease Pathway in Human Neuroblastoma Cells In Vitro
ToxSci Advance Access published on May 2, 2008
Toxicol. Sci. 2008 104: 341-351; doi:10.1093/toxsci/kfn088 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Monica Sanchez, Laura Gastaldi, Monica Remedi, Alfredo Cáceres, and Carlos Landa

Rotenone-Induced Toxicity is Mediated by Rho-GTPases in Hippocampal Neurons
ToxSci Advance Access published on May 13, 2008
Toxicol. Sci. 2008 104: 352-361; doi:10.1093/toxsci/kfn092 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Rochelle W. Tyl, Christina B. Myers, Melissa C. Marr, Carol S. Sloan, Nora P. Castillo, M. Michael Veselica, John C. Seely, Stephen S. Dimond, John P. Van Miller, Ronald N. Shiotsuka, Dieter Beyer, Steven G. Hentges, and John M. Waechter, Jr

Two-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD-1 (Swiss) Mice
ToxSci Advance Access published on April 29, 2008
Toxicol. Sci. 2008 104: 362-384; doi:10.1093/toxsci/kfn084 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Xiaozhong Yu, Sungwoo Hong, and Elaine M. Faustman

Cadmium-induced Activation of Stress Signaling Pathways, Disruption of Ubiquitin-dependent Protein Degradation and Apoptosis in Primary Rat Sertoli Cell-Gonocyte Cocultures
ToxSci Advance Access published on May 6, 2008
Toxicol. Sci. 2008 104: 385-396; doi:10.1093/toxsci/kfn087 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Francesca Di Renzo, Graziella Cappelletti, Maria Luisa Broccia, Erminio Giavini, and Elena Menegola

The Inhibition of Embryonic Histone Deacetylases as the Possible Mechanism Accounting for Axial Skeletal Malformations Induced by Sodium Salicylate
ToxSci Advance Access published on May 14, 2008
Toxicol. Sci. 2008 104: 397-404; doi:10.1093/toxsci/kfn094 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Maureen Mongan, Zongqing Tan, Liang Chen, Zhimin Peng, Maggie Dietsch, Bing Su, George Leikauf, and Ying Xia

Mitogen-activated Protein Kinase Kinase Kinase 1 Protects against Nickel-induced Acute Lung Injury
ToxSci Advance Access published on May 7, 2008
Toxicol. Sci. 2008 104: 405-411; doi:10.1093/toxsci/kfn089 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Lyle D. Burgoon and Timothy R. Zacharewski

Automated Quantitative Dose-Response Modeling and Point of Departure Determination for Large Toxicogenomic and High-Throughput Screening Data Sets
ToxSci Advance Access published on April 25, 2008
Toxicol. Sci. 2008 104: 412-418; doi:10.1093/toxsci/kfn083 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Mary Lynn Bajt, Hui-Min Yan, Anwar Farhood, and Hartmut Jaeschke

Plasminogen Activator Inhibitor-1 Limits Liver Injury and Facilitates Regeneration after Acetaminophen Overdose
ToxSci Advance Access published on May 9, 2008
Toxicol. Sci. 2008 104: 419-427; doi:10.1093/toxsci/kfn091 [Abstract] [Full Text] [PDF] [Request Permissions]  

ERRATUM

ERRATUM
Toxicol. Sci. 2008 104: 428; doi:10.1093/toxsci/kfn112 [Extract] [Full Text] [PDF] [Request Permissions]  

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