Toxicological Sciences

TOXICOLOGICAL HIGHLIGHT

Richard M. Sharpe

"Additional" Effects of Phthalate Mixtures on Fetal Testosterone Production
ToxSci Advance Access published on June 25, 2008
Toxicol. Sci. 2008 105: 1-4; doi:10.1093/toxsci/kfn123 [Extract] [FREE Full Text] [PDF] [Request Permissions]  

REVIEWS

Get checked abstract Sonya M. Billiard, Joel N. Meyer, Deena M. Wassenberg, Peter V. Hodson, and Richard T. Di Giulio

Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment
ToxSci Advance Access published on December 20, 2007
Toxicol. Sci. 2008 105: 5-23; doi:10.1093/toxsci/kfm303 [Abstract] [Full Text] [PDF] [Request Permissions]  

FORUM

Get checked abstract Jie Liu and Michael P. Waalkes

Liver is a Target of Arsenic Carcinogenesis
ToxSci Advance Access published on June 19, 2008
Toxicol. Sci. 2008 105: 24-32; doi:10.1093/toxsci/kfn120 [Abstract] [Full Text] [PDF] [Request Permissions]  

BIOTRANSFORMATION AND TOXICOKINETICS

Get checked abstract Matthew J. Zwiernik, Steven Bursian, Lesa L. Aylward, Denise P. Kay, Jeremy Moore, Craig Rowlands, Kent Woodburn, Melissa Shotwell, Jong Seong Khim, John P. Giesy, and Robert A. Budinsky

Toxicokinetics Of 2,3,7,8-TCDF and 2,3,4,7,8-PeCDF in Mink (Mustela vison) at Ecologically Relevant Exposures
ToxSci Advance Access published on June 19, 2008
Toxicol. Sci. 2008 105: 33-43; doi:10.1093/toxsci/kfn118 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

ENVIRONMENTAL TOXICOLOGY

Get checked abstract Min He, Jiyang Cai, Young-Mi Go, Jennifer M. Johnson, W. David Martin, Jason M. Hansen, and Dean P. Jones

Identification of Thioredoxin-2 as a Regulator of the Mitochondrial Permeability Transition
ToxSci Advance Access published on June 11, 2008
Toxicol. Sci. 2008 105: 44-50; doi:10.1093/toxsci/kfn116 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Bibek Sharma and Reynaldo Patiño

Exposure of Xenopus laevis Tadpoles to Cadmium Reveals Concentration-dependent Bimodal Effects on Growth and Monotonic Effects on Development and Thyroid Gland Activity
ToxSci Advance Access published on June 14, 2008
Toxicol. Sci. 2008 105: 51-58; doi:10.1093/toxsci/kfn119 [Abstract] [Full Text] [PDF] [Request Permissions]  

IMMUNOTOXICOLOGY

Get checked abstract Hee Kyong Bae and James J. Pestka

Deoxynivalenol Induces p38 Interaction with the Ribosome in Monocytes and Macrophages
ToxSci Advance Access published on May 22, 2008
Toxicol. Sci. 2008 105: 59-66; doi:10.1093/toxsci/kfn102 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Maoxiang Li and James J. Pestka

Comparative Induction of 28S Ribosomal RNA Cleavage by Ricin and the Trichothecenes Deoxynivalenol and T-2 Toxin in the Macrophage
ToxSci Advance Access published on June 4, 2008
Toxicol. Sci. 2008 105: 67-78; doi:10.1093/toxsci/kfn111 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Darrell R. Boverhof, Connie M. Wiescinski, Phil Botham, David Lees, Eric Debruyne, Marina Repetto-Larsay, Gregory Ladics, Denise Hoban, Armin Gamer, Marina Remmele, Weizheng Wang-Fan, Ludwig G. Ullmann, Jyotigna Mehta, Richard Billington, and Michael R. Woolhiser

Interlaboratory Validation of 1% Pluronic L92 Surfactant as a Suitable, Aqueous Vehicle for Testing Pesticide Formulations Using the Murine Local Lymph Node Assay
ToxSci Advance Access published on June 12, 2008
Toxicol. Sci. 2008 105: 79-85; doi:10.1093/toxsci/kfn117 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Scott E. Loveless, Denise Hoban, Greg Sykes, Steven R. Frame, and Nancy E. Everds

Evaluation of the Immune System in Rats and Mice Administered Linear Ammonium Perfluorooctanoate
ToxSci Advance Access published on June 16, 2008
Toxicol. Sci. 2008 105: 86-96; doi:10.1093/toxsci/kfn113 [Abstract] [Full Text] [PDF] [Request Permissions]  

IN VITRO TOXICOLOGY AND ALTERNATIVE TESTING

Get checked abstract Jinghai J. Xu, Peter V. Henstock, Margaret C. Dunn, Arthur R. Smith, Jeffrey R. Chabot, and David de Graaf

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury
ToxSci Advance Access published on June 3, 2008
Toxicol. Sci. 2008 105: 97-105; doi:10.1093/toxsci/kfn109 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Nicholas M. Radio, Joseph M. Breier, Timothy J. Shafer, and William R. Mundy

Assessment of Chemical Effects on Neurite Outgrowth in PC12 cells Using High Content Screening
ToxSci Advance Access published on June 6, 2008
Toxicol. Sci. 2008 105: 106-118; doi:10.1093/toxsci/kfn114 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Joseph M. Breier, Nicholas M. Radio, William R. Mundy, and Timothy J. Shafer

Development of a High-Throughput Screening Assay for Chemical Effects on Proliferation and Viability of Immortalized Human Neural Progenitor Cells
ToxSci Advance Access published on June 11, 2008
Toxicol. Sci. 2008 105: 119-133; doi:10.1093/toxsci/kfn115 [Abstract] [Full Text] [PDF] [Request Permissions]  

NEUROTOXICOLOGY

Get checked abstract Desire Tshala-Katumbay, Victor Monterroso, Robert Kayton, Michael Lasarev, Mohammad Sabri, and Peter Spencer

Probing Mechanisms of Axonopathy. Part I: Protein Targets of 1,2-Diacetylbenzene, the Neurotoxic Metabolite of Aromatic Solvent 1,2-Diethylbenzene
ToxSci Advance Access published on May 22, 2008
Toxicol. Sci. 2008 105: 134-141; doi:10.1093/toxsci/kfn103 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Zahidul Islam, Colleen C. Hegg, Hee Kyong Bae, and James J. Pestka

Satratoxin G–Induced Apoptosis in PC-12 Neuronal Cells is Mediated by PKR and Caspase Independent
ToxSci Advance Access published on June 4, 2008
Toxicol. Sci. 2008 105: 142-152; doi:10.1093/toxsci/kfn110 [Abstract] [Full Text] [PDF] [Request Permissions]  

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY

Get checked abstract Kembra L. Howdeshell, Vickie S. Wilson, Johnathan Furr, Christy R. Lambright, Cynthia V. Rider, Chad R. Blystone, Andrew K. Hotchkiss, and Leon Earl Gray, Jr

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner
ToxSci Advance Access published on April 14, 2008
Toxicol. Sci. 2008 105: 153-165; doi:10.1093/toxsci/kfn077 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

Get checked abstract Sheller Zabihi, Parri Wentzel, and Ulf J. Eriksson

Maternal Blood Glucose Levels Determine the Severity of Diabetic Embryopathy in Mice with Different Expression of Copper-Zinc Superoxide Dismutase (CuZnSOD)
ToxSci Advance Access published on May 22, 2008
Toxicol. Sci. 2008 105: 166-172; doi:10.1093/toxsci/kfn101 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Kaberi P. Das, Brian E. Grey, Robert D. Zehr, Carmen R. Wood, John L. Butenhoff, Shu-Ching Chang, David J. Ehresman, Yu-Mei Tan, and Christopher Lau

Effects of Perfluorobutyrate Exposure during Pregnancy in the Mouse
ToxSci Advance Access published on May 28, 2008
Toxicol. Sci. 2008 105: 173-181; doi:10.1093/toxsci/kfn099 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Daniel A. Symonds, Istvan Merchenthaler, and Jodi A. Flaws

Methoxychlor and Estradiol Induce Oxidative Stress DNA Damage in the Mouse Ovarian Surface Epithelium
ToxSci Advance Access published on May 22, 2008
Toxicol. Sci. 2008 105: 182-187; doi:10.1093/toxsci/kfn100 [Abstract] [Full Text] [PDF] [Request Permissions]  

RESPIRATORY TOXICOLOGY

Get checked abstract Michael T. Borchers, Scott C. Wesselkamper, Bryan L. Eppert, Gregory T. Motz, Maureen A. Sartor, Craig R. Tomlinson, Mario Medvedovic, and Jay W. Tichelaar

Nonredundant Functions of β and T Cells in Acrolein-Induced Pulmonary Pathology
ToxSci Advance Access published on May 29, 2008
Toxicol. Sci. 2008 105: 188-199; doi:10.1093/toxsci/kfn106 [Abstract] [Full Text] [PDF] [Request Permissions]  

SAFETY EVALUATION

Get checked abstract Michela Carbonatto, Ping Yu, Mauro Bertolino, Enrico Vigna, Stephanie Steidler, Laura Fava, Chiara Daghero, Bruno Roattino, Manuela Onidi, Michele Ardizzone, Sergio Peano, Jennifer Visich, Derek Janszen, Stacey Dillon, and Rafael Ponce

Nonclinical Safety, Pharmacokinetics, and Pharmacodynamics of Atacicept
ToxSci Advance Access published on June 2, 2008
Toxicol. Sci. 2008 105: 200-210; doi:10.1093/toxsci/kfn105 [Abstract] [Full Text] [PDF] [Supplementary Data] [Request Permissions]  

SYSTEMS TOXICOLOGY

Get checked abstract Christy C. Bridges, Lucy Joshee, and Rudolfs K. Zalups

MRP2 and the DMPS- and DMSA-Mediated Elimination of Mercury in TR^– and Control Rats Exposed to Thiol S-Conjugates of Inorganic Mercury
ToxSci Advance Access published on May 28, 2008
Toxicol. Sci. 2008 105: 211-220; doi:10.1093/toxsci/kfn107 [Abstract] [Full Text] [PDF] [Request Permissions]  

Get checked abstract Monicah A. Otieno, Nicole Bavuso, Joseph Milano, Linda Foster-Brown, Khanh-Hui Bui, Yan Li, Thomas Hudzik, Debra Wescott, Calvert Louden, Martin Dyroff, and François Pognan

Mechanistic Investigation of N,N-Diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide–Induced Insulin Depletion in the Rat and RINm5F Cells
ToxSci Advance Access published on June 6, 2008
Toxicol. Sci. 2008 105: 221-229; doi:10.1093/toxsci/kfn108 [Abstract] [Full Text] [PDF] [Request Permissions]  

ERRATUM

ERRATUM
Toxicol. Sci. 2008 105: 230; doi:10.1093/toxsci/kfn129 [Extract] [Full Text] [PDF] [Request Permissions]  

ERRATUM
Toxicol. Sci. 2008 105: 231; doi:10.1093/toxsci/kfn143 [Extract] [Full Text] [PDF] [Request Permissions]  

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